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Language: English French. The cost implications of using intravenous and oral linezolid instead of intravenous vancomycin in Canadian clinical practice have not been examined. Health care resource use associated with linezolid and vancomycin therapy was estimated for patients in Quebec, based on expert opinion. Costs were assigned to health care resources antibiotics, medical supplies, laboratory testing and health care professional time based on unit prices. Therapy duration, length of inpatient treatment and discharge rates were varied in sensitivity analyses.