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Patients with schizophrenia make more errors than healthy subjects in the antisaccade task. While the precise origin of this deficit is not clear, it has been connected to aberrant dopaminergic and cholinergic neuromodulation. The computational model SERIA stochastic early reaction, inhibition, and late action was employed to separate the contribution of inhibitory control and action selection to empirical reaction times and error rates. Modeling suggested that levodopa improved action selection at the cost of increased reaction times but did not have a significant effect on inhibitory control. Rather, levodopa improved the ability to select correct actions. However, inhibitory control was modulated by cholinergic drugs. This approach may provide a starting point for future computational assays that differentiate neuromodulatory abnormalities in heterogeneous diseases like schizophrenia.
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Molfile expand. A molecular entity capable of accepting a hydron from a donor Br o nsted acid. Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
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