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Tacrolimus is an immunosuppressant used to prevent organ rejection of solid organ transplants and for treatment of a variety of auto-immune diseases e. It can also be used to prevent graft-versus-host disease after haematopoietic stem cell transplant. It can be intended for long term use. Tacrolimus works by suppressing the immune system to prevent organ rejection and graft-versus-host disease. While taking Tacrolimus, you should be seeing your specialist doctor regularly to ensure that your treatment is optimized and to address any concerns relating to your treatment.

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Tacrolimus FK is a macrolide derived from the soil organism Streptomyces tsukudaiensis which, despite having a different structure to CsA, similarly inhibits NF-AT activation. Mark G. Tacrolimus is a microbial product isolated from the organism Streptomyces tsukubaensis. It binds to an intracellular receptor and subsequently binds to calcineurin https://providenceac.org and inhibits the calcineurin pathway that stimulates the nuclear factor, NFAT. The action resembles that of cyclosporine both drugs are calcineurin inhibitors, although the cellular receptors differ. By inhibiting the action of NFAT, tacrolimus decreases synthesis of inflammatory cytokines.

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