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In this case report, we describe a year-old patient with a large grade 2 pancreatic neuroendocrine tumour pNET with spleen metastasis. Eight years after the initial diagnosis, he was admitted for symptomatic and refractory hypercalcaemia, due to calcitriol synthesis by the liver metastasis. In this period, the liver metastasis had progressed despite chemo- and immunotherapy. Patient underwent an additional extend hemihepatectomy, from which he recovered well with normalization of calcium levels. Pancreatic neuroendocrine tumours pNETs are rare neoplasms that arise from islet cells. Although these are generally present at diagnosis, secondary hormonal secretion develops in minority of patients.
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In contrast, the same dose of 1, OH 2D3 caused a 3-fold increase in calcium absorption, which lasted more than 48 h. At the end of the infusion period, calcium absorption was 3-fold higher than that in vehicle-infused controls, but fell to pretreatment levels by 24 h after removing the minipumps. The rapid clearance of OCT is probably due to its low affinity for the serum vitamin D-binding protein. In summary, our results indicate that the pharmacokinetic properties of OCT https://www.chickasaw.net are responsible at least in part for its low calcemic activity. Furthermore, comparison of the transient elevation of calcium absorption by OCT with its more prolonged effects on PTH and calbindin D9k indicates that each action of vitamin D compounds has a distinct biological half-life.
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Calcitriol is a pacemaker hormone that stimulates the qualifying absorption of calcium and do resorption, which can make to hypercalcemia and hypercalciuria.
Physicochemical properties: Calcitriol is a white crystalline powder, slightly soluble in methanol, ethanol, ethyl acetate and relatively insoluble in water.
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Due to the relatively short pharmacological subclavian arteries are looped with Silastic. Am J Med ; Magnesium-containing preparations.
Vitamin D is normally obtained primarily from sunlight acting on the skin. It is also consumed in the diet in oily fish and milk products. Calcitriol acts as a hormone in the body, controlling the absorption of calcium and phosphate from the https://khn.org gut, the levels of calcium and phosphate in the blood and the normal healthy turnover of bone. People who have reduced kidney function can't convert enough vitamin D into calcitriol. This can lead to problems with calcium and phosphate metabolism, reduced absorption of calcium and phosphate from the gut, low levels of calcium in the blood and various bone disorders.
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