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Bupropion inhibits dopamine and noradrenalin reuptake, thus, increasing the level of these neurotransmitters in the synapse. It is also a nicotine antagonist and is approved for smoking cessation. Like other antidepressants, it carries a warning for increased suicidal ideation. It increases blood levels of a range of medications through its inhibition of hepatic P cytochrome 2D6 enzyme.
It also interacts with monoamine oxidase MAO inhibitors to create a potentially fatal reaction. Monoamine oxidase inhibiting antidepressants are not currently widely used, but weaker inhibitors, such as the antibiotic linezolid and the antituberculosis agent isoniazid, still have the potential to create the interaction.