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Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury 9. It may also be caused by musculoskeletal injury 5. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. Initially approved by the FDA in, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity https://plushcare.com by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm Label. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Tizanidine is indicated for the relief of muscle spasticity, which can interfere with daily activities. The general recommendation is to reserve tizanidine use for periods of time when there is a particular need for relief, as it has a short duration of action Label, Spasticity is an increase in muscle accompanied by uncontrolled, repetitive contractions of skeletal muscles which are involuntary. This drug decreases heart rate and blood pressure in humans 4, 6. Despite this, rebound hypertension and tachycardia along with increased spasticity can occur when tizanidine is abruptly discontinued 8.
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Tizanidine is used alone or in conjunction with other standard therapies e. In these patients, tizanidine decreases the number and severity of spasms, alleviates clonus, and improves mobility to a greater extent than does placebo.
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