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The etoricoxib dose should not exceed 60 mg once daily in patients with mild hepatic insufficiency Child-Pugh score 5 to 6, and 60 mg every other day in patients with moderate hepatic insufficiency Child-Pugh score 7 to 9. Renal insufficiency has little impact on etoricoxib pharmacokinetics and no dosage adjustment is required Agrawal et al a.


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