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DOI: PMID: The addition of ovarian function suppression OFS for 5 years to tamoxifen TAM for treatment of premenopausal patients with breast cancer after completion of chemotherapy has beneficial effects on disease-free survival DFS. This study evaluated the efficacy of adding 2 years of OFS to TAM in patients with hormone receptor—positive breast cancer who remain in a premenopausal state or resume ovarian function after chemotherapy. Ovarian function was assessed every 6 months for 2 years since enrollment on the basis of follicular-stimulating hormone levels and vaginal bleeding history. DFS was defined from the time of enrollment to the time of the first event.

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Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow.

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