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Lisinopril is an angiotensin converting enzyme inhibitor ACEI used to treat hypertension, heart failure, and myocardial infarction. Lisinopril was granted FDA approval on 29 December A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Lisinopril is an angiotensin converting enzyme inhibitor used to treat hypertension, heart failure, and myocardial infarction. Angiotensin II constricts coronary blood vessels and is positively inotropic, which under normal circumstances, would increase vascular resistance and oxygen consumption. Comprehensive structured data on known drug adverse effects with statistical prevalence. Structured data covering drug contraindications.
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Oral solution: Orphan designation for treatment of primary hypertension with complications and secondary hypertension in pediatric patients ages 0 through 16 years of age. Adjust dose to blood pressure response; doses up to 80 mg have been used but do not appear to have a greater effect. Taking diuretic: Discontinue diuretic for days before initiating lisinopril to reduce chance of hypotension; may resume diuretic if blood pressure is not controlled; if diuretic cannot be discontinued, initial dose of lisinopril 2. ACE inhibition also causes an increase in bradykinin levels, which putatively mediates angioedema; in comparison with other patients, a higher incidence of angioedema caused by ACE inhibitors has been observed in black patients. A dry hacking cough may occur within a few months of initiating drug therapy with ACE inhibitors; exclude other causes of cough before discontinuing therapy. Cholestatic jaundice associated with ACE inhibitors; discontinue if marked elevation of hepatic transaminases or jaundice occurs. Coadministration with mTOR inhibitors eg, temsirolimus, everolimus may increased risk for angioedema.
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