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We excluded treatment arms of targeted immune modulators without concomitant methotrexate. Our population of interest for indirect comparisons was patients who had active arthritis despite treatment with a disease-modifying antirheumatic drug. We also excluded studies that switched patients from the placebo group to the active treatment if they had an unsatisfactory response at a specific point in time during the study. The underlying assumption for indirect comparisons to be valid is that the relative 52 efficacy of an intervention is consistent across included studies. Included targeted immune modulator-studies primarily differ in study duration, https://www.drugs.com disease duration, concomitant treatments, and some other baseline characteristics.

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