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Adjunctive therapy to diet and exercise to improve glycemic control in adults with type 2 diabetes. Elderly patients are more likely to have decreased renal function; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases. Concomitant administration of insulin and insulin secretagogues e. Withholding of food and fluids during surgical or other procedures may increase risk for volume depletion, hypotension, and renal impairment; therapy should be temporarily discontinued while patients have restricted food and fluid intake. Not indicated for use in patients with type 1 diabetes mellitus that are insulin dependent due to lack of efficacy. Decreases hepatic glucose production; decreases GI glucose absorption; increases target cell insulin sensitivity.
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