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Tizanidine is a centrally acting alpha 2-adrenergic agonist that relieves spasticity by increasing presynaptic inhibition of the motor neurons. From: Neuromuscular Case Studies, Jennifer A. Elliott, in Current Therapy in Pain, Tizanidine had been used predominantly in the management of spasticity; however, it has also proved useful for a variety of painful conditions. As to its efficacy in the management of spasticity, tizanidine compares favorably with both baclofen and and seems to cause less muscle weakness than baclofen and a lower incidence of sedation than.
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