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Herrero—Vanrell, A. Molina—Martinez, M. Refojo, J. Rodriguez—Cabello, M. Abstract: : Purpose: The aim of this work was to prepare and characterize microparticles of a thermo—responsive poly Val—Pro—Al—Val—Gly loaded with dexamethasone phosphate for intraocular administration.
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Received 4 July Conclusion: Based on these results, it is reasonable to believe that the proposed Dex-SA-FFFE nanoparticles might have great application for the treatment of anterior uveitis. Keywords: drug-peptide conjugate, self-assembly, ocular inflammation, in vivo, nanoparticle. Uveitis, a term encompassing a variety of intraocular inflammatory disorders, is one of the leading causes of blindness in developed countries. Although significant advances in pharmaceutical technologies for ophthalmic steroid delivery have been achieved, the development of a novel, superior system with high drug payload for ocular steroid delivery is still urgently required.
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