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Bleeding tendency is usually mild. Diagnosis is based on low levels of VWF antigen and abnormal ristocetin cofactor activity. Treatment involves control of bleeding with replacement therapy cryoprecipitate or pasteurized intermediate-purity factor VIII concentrate or desmopressin. Desmopressin may be a useful treatment depending on the type of VWD a patient has. It is an analog of antidiuretic hormone vasopressin that stimulates the release https://www.webmd.com of VWF into the plasma and may increase levels of factor VIII.
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Desmopressin is a synthetic vasopressin analog with antidiuretic action that has been used in enuretic children since the late s. From: Handbook of Clinical Neurology,
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