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Common side effects include sleepiness, dry mouth, headache, and abdominal pain. It was patented in and came into medical use in Cetirizine's primary indication is for hay fever and other allergies. Because the symptoms of itching and redness in these conditions are caused by histamine acting on the H 1 receptor, blocking those receptors temporarily relieves those symptoms. Cetirizine acts as a highly selective antagonist of the histamine H 1 receptor. Cetirizine crosses the blood—brain barrier only slightly, and for this reason, it produces minimal sedation compared to many other antihistamines. Cetirizine does not undergo extensive metabolism.
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Our patients with rheumatoid allergic rhinoconjunctivitis occasionally present cyclical clinical symptoms. A rail daily dose of cetirizine 10 mg might be used for these problems.
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