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More macrophages are recruited afterwards from the bloodstream, and are in charge of maintaining the infection in the host Dannenberg, Dannenberg Though it is unknown if the bacteria interact with one or more of these receptors during in vivo infection, the results of in vitro experiments suggest that the macrophage response depends on the type of receptor with which the bacteria interact. Their interaction with Fc receptors increases the production of reactive oxygen intermediates and allows the fusion of the bacteria-containing phagosomes with lysosomes Armstrong The interactions of mycobacteria with members of the Toll-like receptor family have been studied for some years. Regardless of the receptor with which the bacteria interact, it has been observed that the cellular cholesterol present in the macrophage cell membrane is an essen- tial molecule for the internalization of the bacteria Gatfield It is believed that cellular cholesterol works as a direct anchorage point for the bacterium and stabilizes its interaction with the macrophage membrane.


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