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Meta-analysis has demonstrated a significant benefit of adjuvant antiestrogens on both recurrence rates and mortality from breast cancer in postmenopausal women. The main concern is the increased number of endometrial cancers in tamoxifen-treated patients. Toremifene Fareston, a newer antiestrogen synthesized in in Finland, has been studied in animal experiments and clinical trials in metastatic breast cancer. Shortly thereafter, the International Breast Cancer Study Group also began planning adjuvant trials of toremifene. The study design of all of these trials and very preliminary safety results of the Finnish trial will be discussed. It was first started in four University Cancer Clinics but was later extended to all nine cancer clinics in Finland. The study is being conducted by the Finnish Breast Cancer Group, an independent scientific group. The duration of treatment is 3 years, and both the efficacy and side effects of the therapies are being explored.
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