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Paxil is an antidepressant that is used for long-term pharmacotherapy of anxiety and panic disorders. The favorable tolerability profile of Paxil, as well as the lack of addiction in long-term use, significantly increase the adherence of patients to the mental illness treatment. A wide range of psychoactive effect of Paxil makes it possible https://civicscience.com to use the drug in the treatment of serious psychological disorders, including. The pharmacological effect of the active ingredient Paroxetine lies in the blockade of serotonin transport in the central and peripheral nervous system. Under the influence of Paxil, serotonin is released from the nerve cells and accumulates in various parts of the brain. In addition, maintenance doses of Paxil up to 40 mg should be used within 6 months after the disappearance of the main symptoms of depressive disorders. Due to the minimum frequency of application once a day, Paxil contributes to an increase in patient adherence to the depressive disorderstreatment. When Paxil is usedwith drugs that increase serotonin concentration SSRI, MOI inhibitors, the risk of hypertensive crisis and severe bradycardia increases. When Paxil interactswith muscle relaxants Mivacurium, Suxamethonium, the duration of the neuromuscular blockincreases.

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The antidepressive activity of Paxil is conditioned by the specific selective serotonin reuptake inhibition in the neurons of the brain. The increase of serotonin in the neurons of the brain regulates pathogenic factors of the depression development. Paxil is a typical serotonin reuptake inhibition but in spite of this, it differs from the common tricyclic and tetracyclic antidepressants. Paroxetine selectively acts to the receptors of serotonin without affecting dopamine and histamine receptors in the brain. As a result, taking Paxil causes less inhibition of the central nervous system and no hypotensive effect.

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