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Patients currently taking aripiprazole will need to switch brands in order to continue to receive subsidised treatment. However, it has a different mechanism of action than other atypical antipsychotics in that it acts as a partial agonist at sub types of dopamine D2 receptors.
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Almost all reported studies have investigated the pharmacokinetics of aripiprazole in healthy volunteers. The pharmacokinetics of dehydroaripiprazole have not been identified in a combined model with aripiprazole. The aims of this study were to develop a combined population pharmacokinetic model for both aripiprazole and its active metabolite, dehydroaripiprazole, in https://www.solvhealth.com psychiatric patients and to identify to what extent the genetic polymorphisms of cytochrome P CYP enzymes contribute to the variability in pharmacokinetics PK. A one-compartment model with first-order kinetics for aripiprazole and dehydroaripiprazole each was developed to describe simultaneously the concentration data. The absorption rate constant was fixed to 1. The typical value of apparent distribution volume of aripiprazole was estimated to be l.
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